Periorbital or Preseptal Cellulitis

Warning

Clinical features

  • Cellulitis involving the orbit
  • Swelling around the eye
  • Impaired eye opening, eye movement or visual acuity

Anaerobic infection is a particular risk in diabetes, immunocompromise, or penetrating injury 

Investigations

  • Blood culture
  • Swab of discharge from superficial lesions for culture

Infection Control

Basic universal precautions

Treatment

Discuss patient with Ophthalmology

 

CO-AMOXICLAV IV 1.2g 8 hourly

For true penicillin allergy:

Discuss with Microbiology

IV to Oral switch

CO-AMOXICLAV PO 625mg 8 hourly

Editorial Information

Last reviewed: 21/04/2026

Next review date: 21/04/2029