Evidence grading for HIV indicator conditions

HIV transmission elimination
Public Health Scotland

Evidence grading for HIV indicator conditions (where HIV test is recommended), defined by having an undiagnosed HIV prevalence of at least 1 per 1000 (from draft UK HIV Testing Guidelines 2026)

 

Indicator condition 

Strength of 

recommendation (1/2) 

Grade of 

evidence (A–D) 

Community-acquired pneumonia 

(requiring hospital admission) 

1 

 

B 

C for CAP where not admitted 
Hepatitis A  1  B
Hepatitis B or C (acute or chronic)   1  B 
Herpes zoster   1 aged <60  B  
Lymphoma  1  B 
Mononucleosis-like illness  

1 aged <60 

2 aged >60 

 B  
Oral hairy leukoplakia  1 B
Sexually transmitted infection   1 B

Unexplained leukocytopenia/ 

thrombocytopenia lasting >4 weeks1  

 1 B
Unexplained lymphadenopathy   1 B
Unexplained weight loss  1 C
Cervical dysplasia   1 C
Invasive pneumococcal disease   1 C
Seborrheic dermatitis/exanthema   1 aged <60  C
Unexplained oral/oesophageal candidiasis 

1 

2 aged >60** 

 C 
Visceral leishmaniasis   1 C
Anal cancer/dysplasia   2 C
Unexplained chronic diarrhoea   2 C
Peripheral neuropathy  2 C
Mononeuritis  2 C
Primary lung cancer  2 D
Unexplained fever   2 C
Candidaemia   2 D
Guillain–Barré syndrome  2 C

1Confirmed result outside local lab reference range.