The table below brings together some common areas where prescribers may be able to take action. This list is not exhaustive and does not replace individual clinical judgement. For more detail see Detail by therapeutic area based on amalgamated medication assessment tool.
Please note that the table below may need to be scrolled horizontally or vertically in order to view all information, depending on your device.
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Drugs poorly tolerated in frail adults
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High-risk clinical scenarios |
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Digoxin (> 125 micrograms)
Benzodiazepines/z-drugs
Antipsychotics (inc. phenothiazines)
Anticholinergics (incl. TCAs)
Combination analgesics
NSAIDs
Sulfonylureas
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Cumulative Toxicity tool
Medication Sick Day Guidance
Dehydration with
- Metformin
- ACEI/ARB
- Diuretics
- NSAID
Three of NSAID, ACEI/ARB, diuretic, metformin
DMARD – no monitoring
QT interval prolongation |
NSAID + CKD/CHF/CV risk
NSAID + age >65 (without PPI)
NSAID + history of peptic ulcer
NSAID + antithrombotic
Glitazone + CHF
TCA + CHF
Warfarin + macrolide/quinolone
≥2 anticholinergics (Anticholinergic Burden Tool)
Three of antipsychotic, opioid, antidepressant, gabapentinoid, benzodiazepine/z-drug
Antiplatelet + anticoagulant
Antipsychotic in dementia
Mirabegron + elevated BP
Serotonin syndrome |