Formulary additions (ratified at June TAMSG)
- Amivantamab solution for (subcutaneous) injection 1600mg, 2240mg (Restricted: Hospital use only) indication as per SMC advice 2834.
- Amivantamab concentrate for solution for infusion 350mg/7ml (Restricted: Hospital use only) additional indication added for SMC advice 2834.
- Durvalumab concentrate for solution for infusion 50mg/ml (Restricted: Hospital use only) (additional indication: SMC2818).
- Enfortumab vedotin powder for concentrate for solution for infusion 20mg, 80mg (Restricted: Hospital use only) indication as per SMC advice 2842.
- Impilimab concentrate for solution for infusion 5mg/mL (Restricted: Hospital use only) (additional indication: NCMAG 216).
- Lazertinib tablets 80mg, 240mg (Restricted: Hospital use only) indication as per SMC advice 2834.
- Nivolumab concentrate for solution for infusion 10mg/mL (40mg/4mL, 100mg/10mL, 120mg/12mL, 240mg/24mL) (Restricted: Hospital use only) (additional indication: NCMAG216).
- Omega-3-acid ethyl esters: Capsules 1,000 mg (docosahexaenoic acid 380mg, eicosapentaenoic acid 460mg) (Restricted: Specialist recommendation only).
- Talquetamab solution for injection 2mg/ml, 40mg/ml (Restricted: Hospital use only) indication as per SMC advice 2863.
Other formulary additions
These will be ratified at next TAMSG
- Recombinant human insulin analogues (Formulary: Endocrine) | Right Decisions
- Insulin Lispro injection 100 units/ml, 3mL pre-filled pen added: Lyumjev Junior Kwikpen®.
- Non-sedating antihistamines (Formulary: Respiratory) | Right Decisions
- Added new indication: fexofenadine hydrochloride tablets 180mg for symptomatic relief of chronic idiopathic urticaria.
Formulary deletions
These will be ratified at next TAMSG
- F408: Disposal of medicinal products: removed as not therapeutic guidance
- F349: Long-acting antimuscarinic bronchodilators (LAMA) in COPD
- Inhaled corticosteroids (ICS) (Formulary: Respiratory) | Right Decisions
- Beclometasone, removed: dipropionate aerosol inhalation (Clenil Modulite®) 250 micrograms/metered inhalation (discontinued).
Major formulary amendments
See the 'What's new' section of each monograph.
These will be marked as ratified or ratified at next TAMSG
- Clostridioides Difficile (Antimicrobial) | Right Decisions
- Complete Severity Assessment: added bullet point 'For administration advice in swallowing difficulties or enteral feeding tubes, see section below'.
- Added new section 'Administration in swallowing difficulties or enteral feeding tubes'.
Minor formulary amendments
See the 'What's new' section of each monograph.
These will be ratified at the next TAMSG
- Prostate cancer: gonadorelin analogues, and gonadotrophin-releasing hormone antagonists
- Leuprorelin amendment: removed that it is used first line:
- Inhalational anaesthetics (Formulary: Anaesthesia) | Right Decisions
- Methoxyflurane amendment: Product licence for Penthrox has changed from 18 years and older to 6 years and older. Link to guideline added.
- Angiotensin-converting enzyme (ACE) inhibitors (Formulary: Cardiovascular) | Right Decisions
- added MHRA advice: ACE-inhibitors: Be aware of the distinction between bradykinin- and histamine-mediated angioedema, as treatment strategies differ significantly (June 2026) (www.gov.uk).
- Second generation (Atypical) antipsychotics (Formulary: CNS) | Right Decisions
- Risperidone - amended wording: '250 microgram tablets are NOT recommended to be prescribed as they are not cost effective' to '250 microgram tablets are NOT cost effective, they are NOT recommended to be prescribed, except for those patients on a 250 microgram dose to avoid splitting tablets’.
- Alpha-adrenoceptor blockers (Formulary: Cardiovascular) | Right Decisions
- Doxazosin - amended wording: '8mg tablets are NOT recommended to be prescribed as they are not cost effective' to ‘8mg tablets are NOT cost effective, they are NOT recommended to be prescribed except for patients prescribed 16mg dose’.
- Vaccines and antisera (Formulary: Immunology & Vaccines) | Right Decisions
- Meningococcal B - Bexsero, added: 'Time-limited Meningococcal Group B (MenB) vaccination programme see CMO letter: CMO Letterhead.dot.'
- Devices for diabetes (Formulary: Endocrine) | Right Decisions
- Updated the Insulin / pen compatibility charts to the latest versions.
- Vitamin B group (Formulary) | Right Decisions
- Updated guidelines section for thiamine solution for injection and parenteral vitamins b and c high potency injection.
- Added '(250mg/5mL)' to thiamine solution for injection.
- Skin cleansers and antiseptics (Formulary: Dermatology) | Right Decisions
- Added: link to NHS Highland patient information leaflet 'How to use Potassium permanganate'.
- GP Out of Hours Formulary: Highland HSCP (Formularies) | Right Decisions
- Infection section:
- Amoxicillin: amended Dental abscess from '5 days' to '3 days then review, may need 5 days'.
- Benzylpenicillin: amended 'saline' to 'sodium chloride 0.9%'.
- Phenoxymethylpenicillin: amended dental abscess '5 days' to '3 days then review, may need 5 days'.
- Doxycycline: amended 'Cellulitis 5 days then review (may need 7 days)' to 'Skin and soft tissue infection 5 days'.
- Doxycycline: amended Hospital/Healthcare acquired pneumonia from 'up to 8 days' to '5 days'.
- Co-trimoxazole: amended Hospital/Healthcare acquired pneumonia from 'up to 8 days' to '5 days'.
- Anaesthesia section:
- Added: Penthrox (methoxyflurane) inhalational vapour, liquid 99·9% 3mL.
- Infection section:
- Domperidone and metoclopramide (Formulary: CNS) | Right Decisions
- Domperidone, added: MHRA advice: Domperidone: new contraindication in patients with phaeochromocytoma due to the risk of severe hypertension (July 2026) (www.gov.uk).
- Drugs affecting the immune response (Formulary: Dermatology) | Right Decisions
- Methotrexate 2.5mg tablet: amended from 'specialist initiation only' to 'specialist recommendation only'.
- Immunosuppressants (Formulary: GI) | Right Decisions
- Methotrexate tablets 2.5mg: amended '(s)' to '(Restricted: Specialist recommendation only)'.
- Methotrexate injection pre-filled syringe 7·5mg/0·15mL, 10mg/0·2mL, 12·5mg/0·25mL, 15mg/0·3mL, 17·5mg/0·35mL, 20mg/0·4mL, 22·5mg/0·45mL, 25mg/0·5mL: amended '(s)' to '(Restricted: Specialist initiation only)' and added 'To be administered via subcutaneous injection'.
- Drugs affecting the immune response (Formulary) | Right Decisions
- Methotrexate tablets 2.5mg: amended '(s) to '(Restricted: Specialist recommendation only)'.
- Methotrexate injection pre-filled pen 7·5mg/0·15mL, 10mg/0·2mL, 12·5mg/0·25mL, 15mg/0·3mL, 17·5mg/0·35mL, 20mg/0·4mL, 22·5mg/0·45mL, 25mg/0·5mL, 27·5mg/0·55mL, 30mg/0·6mL: amended '(s)' to '(Restricted: Specialist initiation only)' and added 'To be administered via subcutaneous injection'.
Formulary sections reviewed with no changes
These will be ratified at the next TAMSG
- Items will be added as they are published